Publications

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MARCH 31, 2020

Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections

This article presents a review of the limited literature available on geroprotective and senoremediative interventions that may be investigated to decrease the disease burden of gerolavic infections. This article also highlights a need for rigorous clinical validation of deep aging clocks as surrogate markers of biological age. These could be used to assess the need for, and efficacy of, geroprotective and senoremediative interventions and provide better protection for elderly populations from gerolavic infections.

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SEPTEMBER 2, 2019

Deep learning enables rapid identification of potent DDR1 kinase inhibitors

 

Insilico Medicine have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic feasibility, novelty, and biological activity. We used GENTRL to discover potent inhibitors of discoidin domain receptor 1 (DDR1), a kinase target implicated in fibrosis and other diseases, in 21 days.

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NOVEMBER 15, 2017

Towards natural mimetics of metformin and rapamycin

Aging is now at the forefront of major challenges faced globally, creating an immediate need for safe, widescale interventions to reduce the burden of chronic disease and extend human healthspan.

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NOVEMBER 9, 2017

Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare

 

The increased availability of data and recent advancements in artificial intelligence present the unprecedented opportunities in healthcare and major challenges for the patients, developers, providers and regulators. The novel deep learning and transfer learning techniques are turning any data about the person into medical data transforming simple facial pictures and videos into powerful sources of data for predictive analytics.

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SEPTEMBER 28, 2017

Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration

 

Written and published by Biogerontology Research Foundation staff in collaboration with Northwestern University Feinberg School of Medicine, the Neurobiology Department of Swammerdam Institute of Life Sciences at the University of Amsterdam and the Department of Biomedical and Molecular Sciences of Queen's University School of Medicine, Queen's University.

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SEPTEMBER 5, 2017

druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico

 

Deep generative adversarial networks (GANs) are the emerging technology in drug discovery and biomarker development. In our recent work, we demonstrated a proof-of-concept of implementing deep generative adversarial autoencoder (AAE) to identify new molecular fingerprints with predefined anticancer properties.

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JUNE 16, 2017

The DrugAge database of aging-related drugs

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area.

Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds.

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MAY 22, 2017

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

 

A subset of patients with oral squamous cell carcinoma (OSCC), the most common subtype of head and neck squamous cell carcinoma (HNSCC), harbor dysplastic lesions (often visually identified as leukoplakia) prior to cancer diagnosis.

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FEBRUARY 14, 2017

The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology

 

Recent advances in deep learning and specifically in generative adversarial networks have demonstrated surprising results in generating new images and videos upon request even using natural language as input.

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SEPTEMBER 28, 2016

Design of efficient computational workflows for in silico drug repurposing. Drug Discov Today.

 

Written and published by Biogerontology Research Foundation staff in collaboration with BioTime Inc., Insilico Medicine Inc. and Johns Hopkins University. Authors: Vanhaelen Q, Mamoshina P, Aliper AM, Artemov A, Lezhnina K, Ozerov I, Labat I, Zhavoronkov A.

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SEPTEMBER 24, 2016

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

 

Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc., Pathway Pharmaceuticals, Ltd., Center for Biogerontology and Regenerative Medicine, Moscow Institute of Physics and Technology, University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), D. Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology, and Immunology, Life Extension, George Mason University (School of Systems Biology), and the Engelhardt Institute of Molecular Biology of Russian Academy of Sciences.

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JULY 5, 2016

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data. Mol Pharm.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc., The Mind Research Network and Datalytic Solutions. Authors: Aliper A, Plis S, Artemov A, Ulloa A, Mamoshina P, Zhavoronkov A.

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JULY 2, 2016

Common pathway signature in lung and liver fibrosis. Cell Cycle.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Wake Forest Institute for Regenerative Medicine (Wake Forest School of Medicine), Atlas Regeneration Inc. and Johns Hopkins University. Authors: Makarev E, Izumchenko E, Aihara F, Wysocki PT, Zhu Q, Buzdin A, Sidransky D, Zhavoronkov A, Atala A.

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JUNE 17, 2016

Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma. Cell Cycle.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Biotime, Inc., Johns Hopkins University, Howard University (Epigenetics Laboratory), Retrope, Inc., Vision Genomics, Inc., and Insilico Medicine, Inc. Authors: Zhavoronkov A, Kanherkar RR, Izumchenko E, Teka M, Cantor C, Manaye K, Sidransky D, West MD, Makarev E, Csoka AB.

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JUNE 15, 2016

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

 

Written and published by Biogerontology Research Foundation staff in collaboration with the Buck Institute for Research on Aging, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Moscow Institute of Physics and Technology, Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology and 5Institute for Systems Analysis, Russian Academy of Sciences. Authors: Moskalev A, Chernyagina E, Tsvetkov V, Fedintsev A, Shaposhnikov M, Krut'ko V, Zhavoronkov A, Kennedy BK.

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MAY 8, 2016

Deep biomarkers of human aging: Application of deep neural networks to biomarker development

 

Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc., Pathway Pharmaceuticals, Ltd., Center for Biogerontology and Regenerative Medicine, Moscow Institute of Physics and Technology, University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), D. Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology, and Immunology, Life Extension, George Mason University (School of Systems Biology), and the Engelhardt Institute of Molecular Biology of Russian Academy of Sciences.

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FEBRUARY 16, 2016

Editorial: Should We Treat Aging as a Disease? Academic, Pharmaceutical, Healthcare Policy, and Pension Fund Perspectives

 

Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc. Authors: Zhavoronkov A, Moskalev A.

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JANUARY 4, 2016

Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes

 

Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Laboratory of Genetics of Aging and Longevity), Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences (Laboratory of Molecular Radiobiology and Gerontology), Estonia Infinity Sciences, Inc., University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), and D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology. Authors: Moskalev A, Zhikrivetskaya S, Shaposhnikov M, Dobrovolskaya E, Gurinovich R, Kuryan O, Pashuk A, Jellen LC, Aliper A, Peregudov A, Zhavoronkov A.

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NOVEMBER 30, 2015

Interactome analysis of myeloid-derived suppressor cells in murine models of colon and breast cancer

 

Written and published by Biogerontology Research Foundation staff in collaboration with HiBiotechnology LLC and Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology. Authors: Aliper AM, Frieden-Korovkina VP, Buzdin A, Roumiantsev SA, Zhavoronkov A.

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NOVEMBER 4, 2015

Classifying aging as a disease in the context of ICD-11. Front Genet.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Novartis Pharma AG, Department of Developmental and Molecular Pathways, Novartis Institute for Biomedical Research. Authors: Zhavoronkov A, Bhullar B.

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SEPTEMBER 29, 2015

Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation. Oncotarget.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Canadian Nuclear Laboratories, Insilico Medicine Inc., Emanuel Institute for Biochemical Physics (Russian Academy of Sciences), Moscow Institute of Physics and Technology, Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Semenov Institute of Chemical Physics (Russian Academy of Sciences) and State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC). Authors: Osipov AN, Grekhova A, Pustovalova M, Ozerov IV, Eremin P, Vorobyeva N, Lazareva N, Pulin A, Zhavoronkov A, Roumiantsev S, Klokov D, Eremin I.

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SEPTEMBER 15, 2015

Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells. Oncotarget.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Stanford University Medical Center (Department of Developmental Biology), Ludwig Maximilian University of Munich (Department of Computational Genomics), Ruhr University Bochum (Department of Neurophysiology), Atlas Regeneration, Inc,., and Insilico Medicine, Inc. Authors: Makarev E, Fortney K, Litovchenko M, Braunewell KH, Zhavoronkov A, Atala A.

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SEPTEMBER 7, 2015

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY).

 

Written and published by Biogerontology Research Foundation staff in collaboration with the Buck Institute for Research on Aging, George Mason University (School of Systems Biology), Moscow Institute of Physics and Technology, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences (Laboratory of Postgenomic Studies), Institute of Integrative Biology (Integrative Genomics of Ageing Group). D. Rogachev Center for Pediatric Hematology, Oncology and Immunology, The Judea Regional R&D Center, Pirogov Russian National Research Medical University (The Research Institute for Translational Medicine), Insilico Medicine, Inc., Xspansa, University of Tennessee Health Science Center (Institute of Physiologically Active Compounds of Russian Academy of Sciences, Genetics, Genomics, and Informatics) and Infinity Sciences, Inc. Authors: Moskalev A, Chernyagina E, de Magalhães JP, Barardo D, Thoppil H, Shaposhnikov M, Budovsky A, Fraifeld VE, Garazha A, Tsvetkov V, Bronovitsky E, Bogomolov V, Scerbacov A, Kuryan O, Gurinovich R, Jellen LC, Kennedy B, Mamoshina P, Dobrovolskaya E, Aliper A, Kaminsky D, Zhavoronkov A.

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JUNE 18, 2015

It is time to classify biological aging as a disease. Front Genet.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Oxford University (Biochemistry Department), Ghent University and Heales vzw. Authors: Bulterijs S, Hull RS, Björk VC, Roy AG.

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FEBRUARY 6, 2015

Screening and personalizing nootropic drugs and cognitive modulator regimens in silico. Front Syst Neurosci.

 

Written and published by Biogerontology Research Foundation staff in collaboration with University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), Insilico Medicine, Inc. and Pathway Pharmaceuticals Ltd. Authors: Jellen LC, Aliper A, Buzdin A, Zhavoronkov A.

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FEBRUARY 6, 2015

Longevity expectations in the pension fund, insurance, and employee benefits industries. Psychol Res Behav Manag.

 

Written and published by Biogerontology Research Foundation staff. Authors: Zhavoronkov A.

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JANUARY 7, 2015

Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells

 

Written and published by Biogerontology Research Foundation staff in collaboration with the Polish Academy of Sciences (Institute of Fundamental Technological Research), Johns Hopkins University, Insilico Medicine, Inc., Howard University (Epigenetics Laboratory), Pirogov Russian National Research Medical University, Pathway Pharmaceuticals Ltd., Moscow Institute of Physics and Technology, and George Mason University. Authors: Aliper AM, Csoka AB, Buzdin A, Jetka T, Roumiantsev S, Moskalev A, Zhavoronkov A.

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DECEMBER 22, 2014

Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions

 

Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine, Inc., Boston University and Vision Genomics LLC. Authors: Makarev E, Cantor C, Zhavoronkov A, Buzdin A, Aliper A, Csoka AB.

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MARCH 6, 2014

Genetics and epigenetics of aging and longevity. Cell Cycle.

 

Written and published by Biogerontology Research Foundation staff in collaboration with University of California at Davis (Department of Ophthalmology and Vision Science; School of Medicine), Moscow Institute of Physics and Technology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Komi Science Center of Russian Academy of Sciences (Institute of Biology) and Federal Clinical Research Center of Pediatric Hematology, Oncology, and Immunology. Authors: Moskalev AA, Aliper AM, Smit-McBride Z, Buzdin A, Zhavoronkov A.

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MARCH 3, 2014

Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs. Front Genet.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Department of Biological and Medical Physics). Authors: Zhavoronkov A, Buzdin AA, Garazha AV, Borisov NM, Moskalev AA.

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JANUARY 23, 2014

On multilabel classification methods of incompletely labeled biomedical text data. Comput Math Methods Med.

 

Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Center for Pediatric Hematology, Oncology, and Immunology) and Moscow State University (Chemistry Department). Authors: Kolesov A, Kamyshenkov D, Litovchenko M, Smekalova E, Golovizin A, Zhavoronkov A.

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NOVEMBER 8, 2013

Biomedical progress rates as new parameters for models of economic growth in developed countries. Int J Environ Res Public Health.

 

Written and published by Biogerontology Research Foundation staff. Authors: Zhavoronkov A, Litovchenko M.

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OCTOBER 18, 2013

From personalized medicine to personalized science: uniting science and medicine for patient-driven, goal-oriented research.

 

Written and published by Biogerontology Research Foundation staff. Authors: Zhavoronkov A, Cantor CR.

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